Medical Information Sciences Vortragsreihe (2 CME Punkte) PROF. DR. PETER KRAWITZ

GUEST LECTURE SERIES „MEDICAL INFORMATION SCIENCES“
The guest lecture series Medical Information Sciences will once again be held at the University
of Augsburg (Campus/FAI) and the University Hospital Augsburg on Tuesday evenings at
5:30 pm during this winter term. Please find this week’s lecture invitation below:

PROF. DR. PETER KRAWIT  (Director of the Institute for Genomic Statistics and Bioinformatics, University of Bonn Medical Center)

„GestaltMatcher: an AI that can Delineate Dysfunction from Dysmorphism“

Deep convolutional neural networks (DCNNs) can be trained to recognize and classify rare
genetic disorders based on their characteristic facial features. GestaltMatcher is such an AI
that learned to construct a clinical face phenotype space (CFPS) in which portrait images can
be placed. Distances in between medical images in the CFPS can be used to quantify
syndromic similarities. Cluster analysis in that space reveals close proximity of molecular
pathway diseases and can, therefore, be used to support "lumping decisions". Furthermore,
the pleiotropic genes causing multiple disorders can also result in distinct facial gestalt. Thus,
cluster analysis can also provide evidence for "splitting decisions", that is indication for
different pathomechanisms based on gestalt analysis.

Peter Krawitz studied Medicine and Physics in Munich. He continued his specialization in Medical
Genetics at Charité Berlin and did a postdoc in Bioinformatics. As a clinician scientist, he was able to
identify the disease-causing variants in the gene PIGV in patients with Hyperphosphatasia with
Mental Retardation (aka Mabry syndrome) by exome sequencing in 2009. Peter Krawitz contributed
to establishing next-generation sequencing protocols in routine health care with a research focus on
deep learning methods to analyze medical imaging data.
In 2017 he was appointed a full professor at University Bonn and established the Institute for
Genomic Statistics and Bioinformatics (IGSB)

Date: November 28th 2023 (starting 5:30 pm)
Place: Lecture Hall N2045 (Faculty of Applied Informatics)

The lecture will be live-streamed to
 the conference room of the Institute for Digital Medicine (IDM, Gutenbergstr. 7, 86356
Neusäß, room 01.B001, first floor) and
 the Main Building of the University Hospital Augsburg,