Medical Information Sciences Vortragsreihe (2 CME Punkte) Dr. Yekta Said Can

Referent: Dr. Andreas Raue formerly Head of Data Science Immuno-Oncology & Hematology, Novartis Institutes for BioMedical Research (NIBR), Cambridge, MA, USA

Titel: „ Applications of Systems Biology in Drug Research and Development“

Computational models and analyses play a crucial role in drug research and development across various stages. These models have become an integral part of the drug development process, addressing a range of challenges. There are two main types of approaches used in these applications:
1) Mechanistic models are utilized to address smaller scale biology and engineering related questions. They help optimize drug design, target engagement, dosing, and PK/PD (pharmacokinetics/ pharmacodynamics).
2) Machine learning and statistical models are employed for larger-scale OMICS data analysis. They aid in identifying and characterizing targets, selecting patient populations, and understanding biomarkers of response or resistance. This presentation will showcase recent examples in both areas and explore potential future opportunities for Systems Biology modeling in drug research and development.
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Dr. Andreas Raue's research focuses on exploring and developing novel therapeutic approaches in oncology by harnessing advanced technologies such as single-cell sequencing and deep learning. He earned his Ph.D. from Albert-Ludwigs University in Freiburg, Germany, before relocating to the United States. Over the span of more than a decade, he contributed significantly to the fields of biotechnology and pharmaceuticals, conducting discovery and translational research at Merrimack Pharmaceuticals, HiFiBiO Therapeutics, and Novartis. Throughout his tenure, Dr. Raue and his team successfully advanced numerous projects from initial target identification to clinical trials. Until recently, Dr. Raue led the Immuno-Oncology and Hematology Data Science team at Novartis, spearheading efforts to develop and deliver state-of-the-art therapies aimed at improving outcomes for patients with cancer and blood disorders.
From May 2024 on, Andreas Raue will hold the Chair for Modelling and Simulation of Biological Processes at the University of Augsburg.

Date: April 23rd 2024 (starting 5:30 pm)
Place: Lecture Hall N2045 (Faculty of Applied Informatics)

We once again offer the chance to arrange informal individual meetings with the speaker to discuss related scientific questions. Please send an e-mail to office.bioinf@informatik.uni-augsburg.de to make an individual appointment a few days in advance.